The Endocannabinoid System and Hemp

Human, Hemp, History.

The earliest written recorded use of hemp for health purposes, dates back over forty-seven hundred years1. From the very beginning, this long, evolving, and geographically diverse relationship between human and hemp has always remained multi-faceted. Human interactions with hemp ranged from using stalk and fibrous parts for construction of housing and splicing of ropes, to the production of fabrics. Specifically, hemp seeds were pressed into hemp seed oil and ground into nutritious protein flour and the colorful, aromatic hemp female flowers were used for health and spiritual purposes. Hemp was also burned as an antiseptic, inhaled in combination with and instead of tobacco, and extracted and infused into water hydrolats or oil balms.

                                            CBD Oils

Despite this long-standing relationship between humans and the hemp plant, biological mechanisms by which our bodies interact with various hemp components started emerging only in the 1980’s, when an international group of scientists working in Israel had a major break-through. Led by Prof. Raphael Mechoulam, that critical discovery was of the endocannabinoid system (ECS) – a finding that would positively reshape the future of our relationship with the cannabis plant.


What is the Endocannabinoid System?

Until the 1980’s, we did not understand that humans, as well as many different animals, naturally synthesize chemical transmitters called endocannabinoids. These endocannabinoid molecules interact with the proteins in our brains and various body organs, called cannabinoid receptors 1 and 2 – CB1 and CB2. Hence, the body’s ECS consists of naturally synthesized endocannabinoids, their synthesizing and degrading enzymes, and cannabinoid CB1 and CB2 receptors2. Virtually every organ and cell in human (and mammalian) bodies, contains elements of the endocannabinoid system.

                                        Endocannabinoid System

CB1 receptors are highly prevalent in the brain cells called neurons. The activation of CB1 receptors by the endocannabinoids, regulates neurochemical communication between neurons3. The CB1 receptors are activated by the endocannabinoids, but also by the phytocannabinoids (naturally occurring organic cannabinoid molecules in hemp). In this way, CB1 receptors interact with endogenous endocannabinoids and exogenous phytocannabinoids. Since CB1 receptors are widely distributed throughout the brain, they are involved in regulating many physiological and psychological functions, but they do not control vital body functions like the heart tone or breathing rate. In the brain, CB receptors are the most prevalent G-protein coupled receptors (a large transmembrane protein complex that can regulate activity inside the cells). In addition to the brain, CB1 receptors can be found in virtually every organ in our bodies, with high prevalence in the digestive system, bladder and heart4.

Unlike CB1 receptors, CB2 receptors are strongly associated with the immune system and are predominant in body organs that are involved in amassing the immune system response, such as, the spleen, bone marrow, pancreas, and lungs. Nonetheless, CB2 receptors are also found in the brain, on a type of cell called glia. In the brain, a glia cell subtype called microglia are activated during an injury, or a state of disease, or infection. Microglia respond by producing cytokines, which allow for the immune response to get engaged and for proper cell-to-cell communication to occur. However, unregulated cytokine release or dysfunctional CB2 receptors, can cause neurotoxicity and neuronal death. In contrast, CB2 receptor activation regulates oxidative damage and cytokine release in the brain5.

In addition to the brain and visceral organs, both CB1 and CB2 receptors and endocannabinoids are also found widely in the largest organ of the body – the skin. In the skin, CB1 and CB2 receptors are found in nerve endings, ‘epidermal keratinocytes, and the epithelial cells of hair follicles, sebocytes and eccrine sweat glands’. In this manner, CB1 and CB2 receptors and the ECS form an intricate regulatory and homeostatic network from the deepest to the most superficial cells and tissues.

The endocannabinoids (anandamide (AEA) and 2-arachidonoylglycerol (2-AG)) that target CB receptors are synthesized by our bodies6 and released on demand, during heightened levels of stress on the brain and the body. As such, they serve as one of the body’s regulatory molecules, operating in a negative feedback fashion and regulating abnormal brain-body activity. Endocannabinoids are lipid soluble and are not stored in vesicles, like traditional neurotransmitters. When endocannabinoids are released in the brain, they bind to CB1 and CB2 receptors on neurons and glia.

What is the relationship between the endocannabinoid system and hemp plant?

The recent discovery of the endocannabinoid system and the associated scientific and clinical discoveries, have once again reignited our interest and perhaps even trust in the inherent therapeutic properties of cannabis and its components. Discovery of one of the major phytocannabinoids – CBD in the lab and the green houses, and its recent emergence on the global market, as a safe, non-psychotropic cannabinoid was a game changer. But how does CBD and hemp oil interact with the ECS?

CBD binds to CB1 receptors, but it does not bind in a way that it causes a psychotropic effect. Psychotropic effect is different from a substance being psychoactive. Indeed, even coffee is psychoactive, which means that caffeine fromcoffee, gets into the blood from the digestive system, crosses the blood-brain-barrier, and binds to the caffeine (aka adenosine) receptors in the brain. Caffeine binding to adenosine receptors increases brain activity, by facilitating an increase in release of excitatory neurotransmitter glutamate. Cup of coffeeaffects your behavior accordingly, but it does not cause you to feel ‘high’. Much in the same way as caffeine, CBD affects brain activity, but it does not have psychotropic properties.


CBD binds to and is an allosteric modulator of CB1 receptors.  Unlike THC, it does not bind to the primary binding site of CB1 receptor proteins, but rather at a different, remote site. Bound in this allosteric position, CBD modulates the interactions between the molecules that bind CB1 in the primary binding site, which include  psychotropic substances.  In addition, CBD also interacts with serotonin receptors, vanilloid receptors, a receptor called GPR55, and PPAR nuclear receptors. Thus, CBD has a multitude of targets and functions in the body, within and outside of the ECS7.

What in hemp activates CB2 receptors?

In addition to phytocannabinoids, the hemp plant contains a variety of aromatic terpenes. When properly preserved and processed, the hemp plant can yield several percentages of terpenes in the biomass. Often, the biomass made from distinct hemp strains will contain a variation of terpenes. Terpenes, are not just molecules that give plants their pleasant aromas. Terpenes have their own distinct physiological functions and even interactions with the ECS.


For example, one of the most common terpenes found in hemp is caryophyllene or beta caryophyllene (BCP). BCP is also widespread in hops, peppers, and cloves8. BCP is a selective CB2 receptor activator (agonist). Hemp CBD preparations and full spectrum CBD oils that contain significant levels of BCP, and other terpenes and molecules will more fully engage the endocannabinoid system, regulating brain-body homeostasis.

Here is more great information:

  • EndocannabinoidsAnandamide and 2-Arachidonoylglycerol (2-AG)
  • Endocannabinoid deficiencies are thought to be disorders that stem from the lack of proper ECS functions. These disorders are usually hyperalgesia: Migraines, fibromyalgia, irritable bowel syndrome, neurotransmitter disorders, and epilepsies (Dr. Ethan Russo).


                                                                                      By Dr. Jokūbas Žiburkus, PhD© aka Dr. JZ



  1. Russo, E. B. & McPartland, J. M. (2003) Cannabis is more than simply delta(9)-tetrahydrocannabinol. Psychopharmacology (Berlin).
  2. Mechoulam R, Parker LA. (2013) The endocannabinoid system and the brain. Annu Rev Psychol.
  3. Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M, Watanabe M. (2009) Endocannabinoid-mediated control of synaptic transmission. Physiol Rev.
  4. Shenglong Zou and Ujendra. (2018) Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. International Journal of Molecular Sciences
  5. Caroline Turcotte, Marie-Renée Blanchet, Michel Laviolette, and Nicolas Flamand. (2016) The CB2 receptor and its role as a regulator of inflammation. Cell Mol Life Sci.
  6. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R. (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science
  7. José A. Crippa* Francisco S. Guimarães, Alline C. Campos, and Antonio W. Zuardi (29018) Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
  8. Sharma C, Al Kaabi J, Nurulain SM, Goyal SN, Kamal MA, Ojha S. (2016) Polypharmacological Properties and Therapeutic Potential of beta-Caryophyllene: a Dietary Phytocannabinoid of Pharmaceutical Promise. Curr Pharm Des




Which Hemp CBD Oil to Use: Full Spectrum, Broad Spectrum, PCR Oil, or Isolate?

In the fast-changing global hemp market, new ingredients, products, and definitions are developing at such fast speed that this industry often becomes overwhelming for a lay person, a patient, a regulator, or a hemp-based start-up. Indeed, when one looks at a variety of products online or in hemp or cannabis retail shops, the sheer number of products and brands can be overwhelming. Furthermore, when faced with a variety of hemp products at the retail locations, it is rare to find a well-educated sales person that can confidently explain the difference in the multitude of products.  A good sales person should be able to explain some basic concepts about hemp, phytoactive elements, including phytocannabinoids, explain the differences in the products at hand, and to not overstate hemp’s medicinal value.

While the level of consumer and seller education is evolving, more and more interesting hemp products will enter the market, concurrent with the increasing demand and daily consumption of the whole hemp plant elements, like non-psychotropic phytocannabinoids like cannabidiol (CBD), cannabigerol (CBG), and their acidic forms, CBDA and CBGA, respectively. Given that it is estimated that only few percent of the total population currently knows what CBD is, the market is still at the emergent stage. Yet the small number of people who start discovering how hemp may benefit them, inevitably first look at the products, but then quickly want to learn more about the plant, CBD, and terpenes, as well as potentially learn about the endocannabinoid system.  Education is required before consumers spend tens or hundreds of Euros for an unknown brand or product that has no scientific backing, but instead a great marketing machine. Subsequently, once feeling aware of some of these concepts, consumers surf back into web shops or venture off to retail stores, talk to the consumers on social media, and seek for accredited, legitimate experts that can explain about the products.

                                                                                                                           Hemp CBD Oil Drops


Retail shops of hemp or cannabis offer an unprecedented opportunity not only to educate the public, but to allow for consumers to look at the products much closer, to smell, touch, and try first.  After they have potentially learned some basic information about hemp and the endocannabinoid system, these are some of the most common questions that, typically, follow immediately:

                                 What is the difference between full spectrum hemp oil and CBD oil?

                                What is CBD isolate?

                                How is hemp oil different from hemp seed oil?

                                Which product is good?

……..So, to answer some of these questions we should walk through some of the important definitions below:


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Full Spectrum

Full spectrum hemp oil is typically made from hemp flowers, leaves, and the top stems. Often, the plants are used with the seeds inside of the flowers. When cold extraction methods (example: super critical CO2, cold alcohol) are used to extract the whole plant or its parts, like flowers or upper stalks, the resultant concentrate will contain a whole full spectrum of cannabinoids, flavonoids, chlorophyll, waxes and terpenes. Within hemp, CBD is the most prevalent phytocannabinoid. However, other minor cannabinoids are also present, like CBG (cannabigerol), CBC (cannabichromine), and the acidic cannabinoids (CBDA, CBGA, THCA).

It is thought that the full spectrum oils and natural waxes may provide for the most interactions for a variety of whole plant molecules. Full spectrum oils would then be most in line with the wholistic approach of treating the whole body with the whole plant(s). Florance Hemp CBD Oil 250 is a good example of a full spectrum raw hemp oil with these factors.

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Broad Spectrum

For broad spectrum formulations, the same or select parts of the plants would be used: flowers, leaves, trim, stalks. During heating, extraction process, or post-extraction processing of the concentrate, the oil may lose some of the components mentioned above. Acidic cannabinoids may become completely decarboxylated by heat and some terpenes may also evaporate. Removals of the natural hemp waxes in the extracts may remove terpenes and some cannabinoids. Filtering or processing with heat will further reduce the full spectrum of molecules into the broad spectrum. The most volatile terpenes may also be lost in this post-process.


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PCR stands for phytocannabinoid rich. In this case, typically, using alcohol distillation, the most dominant phytocannabinoids (THC and CBD) and terpenes are separated. This process allows to produce extractions that are 0.0% THC and to preserve a partial set of terpenes from the original plant.  Post-extraction, the extracted and separated terpenes can then be combined back with CBD. PCR oils are typically CBD oils that are 0.0 THC and can be up to 90% CBD and 10% terpenes. Although PCR oils are stripped of some of the beneficial hemp components, they are also effective, can usually be shipped internationally, and should not show any positive THC test in the blood. Furthermore, PCR oils allow to explore for benefits of whether a given person is reacting to CBD and a small subset of terpenes, in the absence of other hemp molecules.

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Isolate or CBD Oils

CBD can be reduced to a powder or crystal form? Yes, this is a natural CBD that comes from the plant. It is not synthesized, but it is isolated from all of the rest of the molecules. It looks like grain flower that dissolves in oil. Thus, CBD isolate is typically 25-50% cheaper than the full spectrum extract. In addition, CBD isolate is often used to infuse other oils, like olive oil, with CBD. However, CBD oil is not hemp oil. CBD can be dissolved in hemp seed, olive, avocado, MCT (medium chain triglyceride oil), and other oils.

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Why would you want CBD in olive oil or MCT or other oils?

From a consumer’s perspective, they are already familiar with olive oil, but they are not with hemp seed oil or hemp oil. MCT oil contains mostly caprylic and capric acids with C8 and C10 carbon chains, respectively. This oil is also popular with the athletes and body builders. Thus, when combined with the ingredients that are known to the consumer and have known benefits, CBD finds its way into our daily diet, on top of the salad or in a smoothie at the gym.

Does this mean that CBD Oil is not as good for me as the PCR or Full Spectrum oils?

Some have criticized hemp as a dirty plant, compared to ‘marijuana’ grown in green houses.  Wait a minute, I though to myself, does one only want to eat tomatoes grown in the green houses? – no! Doesn’t the plant evolve with the environment that surrounds us, while we are evolving with it as well? – yes! Isn’t there ‘dirty marijuana’ and bad products? – yes! The argument that hemp is a great bioremediatory and can suck up everything from the ground is also true about cannabis grown in artificial environments. We should want hemp to give us the cleanest and most complex output of the earth, sun, and wind.

Its all about the quality.

So let’s demystify ‘dirty hemp’ and lets talk about quality ingredients and quality products. As with any food supplement, cosmetic, or medical products, there are good products and bad products. Hemp and hemp products can be pristine, harvested and processed by hand, or they be of poor quality. The same goes for the THC cannabis plants and products. The final quality of the plant and the product depends on many variables, but most importantly on the people and process behind it. Products made from pristine hemp with the highest quality ingredients, formulations, and innovations will stand the test of time. Products made with real scientific substance and care for quality will establish themselves in the market place long term.

Whether consumers pick CBD oil or full spectrum hemp entourage products, they will find their favorite, safe and most effective products with the help of additional research and education. More hemp in our daily food chains is inevitable, so learning what products to select, how to use them, and what to expect after using them is key for hemp regaining its royal thrown with ‘vitamins CBD, CBG, CBC’ and terpenes as their loyal entourage.

Dr. JZ – Jokūbas Žiburkus, PhD (

For more information:

Previously published in Hanf Magazin





Ahhh…this hemp flower smells like lemon*!

Have you ever wondered what is it that you really smell in cannabis plants? Perhaps you thought it is THC or CBD that gives it that ‘skunky’ or ‘tangy’ smell. Or maybe you just never spent enough time thinking about it. Yet, time after time when you smelled different hemp strains, the aromas were distinct, and, as often is the case, so were their euphoric and behavior-eliciting effects. Some cannabis strains and their smells attract and agree with a given user and others simply do not.

Terpenes take entourage center stage.

Cannabis flower and hemp oil aromas, stem from aromatic terpenes and a distinct chemical composition of the plant. The cannabis plant synthesizes phytocannabinoids and terpenes from geranyl phosphate inside the glandular trichomes that also produce cannabinoids. As such, phytocannabinoids and terpenes share a common parent molecule and can be considered to be half-siblings [1]. To date, over 1100 compounds, 200 plus of which are terpenes, have been identified in cannabis. Sadly, the majority of the terpenes are not found in most extracts due to the high volatility and the frequent use of heat or solvents during the extraction process. Some of the predominant terpenes in cannabis are limonene, linalool, pinene, myrcene, and beta caryophyllene [2].

Terpene molecules found in cannabis plants and Florance™ Hemp CBD Oil 150 and Hemp CBD Lozenges for instance, are not unique to cannabis, but are prevalent in other plants, roots, and fruits. For example, limonene is a terpene found in citrus and gives lemons or mandarins a related, but distinct smell. When inhaled through nostrils and mouth cavity, terpenes can activate parts of the brain that process olfactory (smell) information. The brain ‘smell centers’ in turn are connected to the areas of the brain responsible for emotions, moods, and memories. Each one of the aromas activates distinct neuronal networks, thereby initiating distinct behavioral outputs. Certain smells, like peppermint or Florance™ Hemp CBD Mint Eucalyptus Lozenges, invigorate and boost energy levels, while others, like lavender or Florance™ Hemp CBD Oil 1500 hold calming properties. Through the linkage to the memory areas in the brain, smells can instantly evoke vivid moments of distant events correlated to those particular smells, and even generate strong emotions.

Terpenes, ingestion, topical applications.

We ingest terpenes every day by eating fruit and vegetables and other foods. It turns out that cannabis plants and extracts can be dominated or contain some terpenes in high concentrations. Can hemp cannabis terpenes be ingested? Yes, like with foods, hemp oils can also be ingested. When ingested through the mouth, terpenes can get absorbed into the entire body system or exert its effects locally within the gastrointestinal tract. In addition to ingestion, terpenes can also have significant effects through topical applications, acting on the skin cells or the nerve endings in the skin. Our skin contains cannabinoid and other receptors that are bound by terpenes.

Be it in a form of a medicinal extract, vaporizer, or topical cream, terpenes are clearly now at the epicenter of the cannabis world and a significant part of our Florance™ products and philosophy. Our growing understanding of various cannabis component functions, like terpenes, is evolving, as is the relationship between the cannabis plant and humans. The depth of this relationship stands to benefit not only humans, but the entire cannabis-related ecosystem.

* Limonene is a terpene that accounts for some cannabis strains having lemony aromas.

Edited 2018
Original Copyright © Dr. JZ – aka Dr. Jokubas Ziburkus (Canntelligence) 2016.

1. Russo, E.B., Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol, 2011. 163(7): p. 1344-64.
2. Russo, E.B. and J.M. McPartland, Cannabis is more than simply delta(9)-tetrahydrocannabinol. Psychopharmacology (Berl), 2003. 165(4): p. 431-2; author reply 433-4.

CBD For Your Daily Routine: How to Use It to Your Advantage

Cannabidiol (CBD) is a chemical found in the hemp plant. Contrary to public opinion, CBD doesn’t give you a high. That’s caused by THC. In fact, CBD hemp oil contains only trace amounts of THC, less than 0.3% according to legal standards. There are many unique strains of hemp that have a high amount of CBD and a negligibly low amount of THC, allowing for hemp oil manufacturers to produce it in large quantities. The question, then, is how might you take advantage of this in your daily life?

Rich and Rewarding Effects

Many people herald CBD as a fantastic discovery. Why? Well, anecdotal data suggests that it is helpful for mitigating anxiety, accelerating relaxation, and calming the mind. Here are some tips for incorporating CBD oil, and its effects, into your daily life.
Breakfast: A great way to fit CBD into your morning is by consuming it with breakfast. Spray or drop it on your toast, oatmeal, or smoothie as a great way to start your day and brighten your mood!
Post Exercise Routine: Getting tight and stressed muscles from your workout is rewarding, sure, but after a while you just want your body to be pain-free. CBD oil might just be the answer to your post workout woes.
Before Bed: Though hemp oil manufacturers make no claims toward CBD making you sleepy, people have found it useful for night time sleep aid. CBD doesn’t make you tired in the traditional sense, but many people have found that the calming effect it has on their mind allows respite from and endlessly chattering inner dialogue.
As a Safeguard: If you are prone to anxiety induced panic attacks, CBD might be a great tool in your panic prevention belt. Carrying it on you, even if you never choose to use it, is an excellent exercise in caution.

CBD hemp oil does not give you a ‘high’. It simply calms the mind and body in subtle ways. This can help you when you need to focus, sleep, calm down, and relax after a long day. If you would like to learn more about hemp oil companies and premium hemp CBD products as a whole, check out our website.

The Breakdown on Cannabidiol Hemp Oil: What It Is and How It Works

Cannabidiol Hemp Oil

The benefits of hemp and cannabis oil are well known and have grown in popularity in recent years. One product that has gained traction in the hemp market is cannabidiol hemp oil, more commonly known as CBD hemp oil.

What is CBD Hemp Oil?

Most people associate hemp with THC, or tetrahydrocannabinol, which is a psychoactive element present in hemp. However, unlike many hemp oil products that are high in THC, cannabidiol oil is made from low THC hemp. So low in fact (less than 0.3%), that the psychoactive attribute is eliminated from the product. Cannabidiol is actually the second most prevalent cannabinoid in marijuana after THC, although CDB accounts for the majority of the hemp plant’s composition while THC is only present in trace amounts. Since the hemp oil consists mostly of CBD and not THC, it’s non-psychotropic and therefore produces all of the health benefits associated with hemp but without the “high.”

What are the Benefits of Cannabidiol Oil?

Your body has a responsive system, called the endocannabinoid system, which is made up of receptors that react to the presence of cannabinoids in the body. Your body produces its own cannabinoids, which is why most people don’t need to manage their endocannabinoid system. The system regulates a variety of bodily functions including appetite, pain, moods, memory, immune response, cycles of cellular life and death, and sleep. One of the many benefits of CBD oil is maintaining a healthy endocannabinoid system, and thus promoting healthy bodily functions. It can also help with anxiety, inflammation, and chronic pain, all without producing a euphoric feeling.

Are There Any Side Effects?

While everyone reacts differently to any product, there have been no actual findings of adverse effects on the body due to CBD. In fact, scientists from Germany conducted an investigative study to determine if CBD was healthy for human consumption. The results of the study found that cannabidiol is perfectly safe. The findings looked at a variety of physiological interactions with CBD and found that it had no negative effects on blood pressure, body temp, red blood cell count, glucose levels, pH balance, heart rate, and much more.

Many hemp oil companies are jumping on the CBD train, offering hemp CBD products that can help people with their ailments without all of the controversies. It provides a legal, safe alternative that can benefit millions of people.

Looking for a hemp oil manufacturer? Contact us today.

5 Great Hemp-Based Products!

Hemp production is hitting the mainstream these days and there are a great many reasons why. Since agriculturally unique strains of hemp grow to between 10 and 15 feet before they are ready to harvest, the yield is typically quite substantial. This plant looks like bamboo and has just as many, if not more, uses. Here are a few examples.

CBD Hemp Oil

Derived from the seed of the hemp plant, hemp oil products have a high cannabidiol (CBD) content level. This compound is found in unique strains of hemp plants that contain negligible amounts of THC and is used in completely different ways. Some research suggests that CBD is excellent for promoting bodily homeostasis when consumed as an oil, tincture, or applied topically.


The stalk of the hemp plant is very versatile. The fibrous center of the stalk comes apart into strands that can be woven into clothing and other fabrics. This is a budding industry to watch.


Hemp paper is an excellent alternative paper source, which can allow people to loosen their dependence on cutting down trees. Since hemp plants are great for agricultural rotation, they are a quick, renewable source of paper.


You can make flour from the cake of the hemp seed. It might not be the most appetizing treat in the world, but look how much people have managed to do with wheat over the years. The nut can also be used to make bread, milk, granola, and even protein powder.


Biofuel is a pretty big industry that agricultural hemp might crack into. Pressing the hemp seed causes the oil to come out. This oil can be used to power certain combustion engines. So far, the yield per acre has proved less than efficient, but further development is underway. Hemp oil companies are sprouting, paper mills are going green, and fresh hemp food products are hitting the shelves all across America. The many beautiful and clean uses for this under-appreciated plant are coming into play. If you are interested in premium hemp CBD products or would like to learn more about the plant itself, check out our online store today.

Identifying High Quality CBD Hemp Oil

CBD hemp oil is becoming all the rage, growing in popularity for its reputation for balancing the mind, helping with focus, alleviating anxiety, and enhancing sleep. It’s been known to offer a more natural way to lower pain and there’s even some promising new evidence that CBD use may help people quit smoking.

As a result, alongside reputable and well-made products, a market of venture capitalists trying to make easy money have flocked to the CBD hemp oil space. As you might imagine, many of these investors cut corners in order to create a very low-cost product that they can market and sell as “premium.”

This can make it challenging for consumers to distinguish high-quality CBD hemp oil from product that isn’t created with high-quality science, from organic natural sources, or with the LOVE companies like Florance place into our product.

To distinguish high-quality CBD hemp oil from low-quality copycats, it’s important to evaluate the product you’re considering a number of different ways.

It’s The Science

First, take a look at the scientific bona fides behind your CBD hemp oil products. High-quality CBD hemp oil should be pristine, lab-tested products tested at certified health science universities.

Has the product you’re using been developed and backed by industry-leading scientists and researchers? Florance’s team of researchers is second to none in the industry, working at renowned research universities and lab-testing Florance’s products using nothing but the highest-quality, cutting-edge science to deliver the best possible customer experience.

Does your CBD hemp oil contain less than .03% of THC? The goal here is to receive the health and wellness benefits of CBD, not to get high. As such, our oils contain non-psychoactive compounds of the industrial hemp plant. You’ll receive all the benefits of CBD hemp oil with zero intoxication.

Go To The Source

Next, where is your hemp sourced?

As is true in most personal health and wellness products, the quality of the ingredients matters a great deal. At Florance, our products are all sourced from US organic hemp and EU-certified organic hemp products. Our CBD hemp oil contains no pesticides, herbicides, or other harmful contaminants to ensure a superior experience and benefit to our customers.


At Florance, we use “whole plant” CBD hemp oil, meaning oil extracted from all parts of the hemp plant (stem, seeds, and stalks). It is believed utilizing the entire array of constituents found in various parts of the hemp plant work better together, and as such we derive all our products from the entire plant.

Better Development = Better CBD Hemp Oil

Our products have been developed, tested, and refined by world-renowned scientists with years of experience growing organic hemp. We use nothing but the best, hand-selected ingredients in our CBD hemp oil, and operate our business under the strictest of quality control measures to ensure consistency of product. You should demand the same of any product you put in your body.

You owe it to yourself to purchase CBD hemp oil made with science, with nature, and with love. Check out our full range of hemp oil products here!

Top 5 Benefits of CBD Hemp Oil

CBD hemp oil is an intriguing product with a number of compelling benefits observed by its users. It’s non-psychoactive, meaning it does not change the state of mind of the person who uses it. On the other hand, it does appear to produce changes in the body that have been found to carry benefits to the user. Here we will discuss five of the most exciting benefits observed in users of CBD hemp oil.

1. Natural Pain Relief

A study published in the Journal of Experimental Medicine found that CBD significantly reduced pain and chronic inflammation in some mice and rats.

Chronic pain, particularly neuropathic pain, is a major clinical problem that is difficult to treat. However, the results of this study suggest that CBD hemp oil can produced a potent analgesic (pain relieving) effect.

With so many over-the-counter pain medication options consumed daily that contain potent side effects, offering people a natural alternative in CBD hemp oil is an exciting proposition!

2. Anxiety Disorders

A review by Neurotherapeutics, published in the US National Library of Medicine, is suggestive that CBD hemp oil might help to reduce anxiety symptoms experienced by people with certain types anxiety disorders.

Disorders such as general anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, and panic disorder CBD may be beneficial for people with these conditions effective through the use of CBD hemp oil.

The journal entry points out that while prescription medications for these disorders can lead to additional symptoms and unwanted side effects, CBD hemp oil has not shown adverse effects in these cases to date.

3. No High

Another significant benefit of CBD hemp oil is that it does not produce a high. For people wanting the myriad health and wellness benefits of hemp without the mind-altering impact produced by cannabis, CBD hemp oil is a wonderful solution.

This is especially good news for the portion of the population like pregnant and/or nursing women for whom THC would be harmful.

4. Legality

CBD hemp oil is legal at the federal and state level, and is easy to obtain online (make sure your CBD hemp oil is produced by a reputable company using organic products developed and tested in legitimate research universities and facilities).

As opposed to products containing more than 0.3% THC, CBD hemp oil provides access to the health and wellness benefits of cannabinol without the legal headaches associated with cannabis products.

5. Focus

There is anecdotal evidence that CBD hemp oil can help with focus and mental clarity. Users with ADHD and related disorders have reported feeling a much greater sense of singularity in their pursuits when using CBD hemp oil as compared to their previous endeavors.

Everyone has different experiences. This article should not be considered to be medical claims of specific effects. We are merely pointing out some of the general benefits of CBD hemp oil that have been observed and noted by researchers and casual observers alike. As with most things, your mileage may vary. To see if CBD hemp oil is right for you, consider our collection of Full Spectrum Hemp Oils. Cheers!